Grey’s Anatomy

Grey ’s Anatomyhas seen many of its independent characters go , with many being kill off and others being given a more uplifting closing , and the behind - the - fit reason for their departures   have all been dissimilar . The medical drama genre has seen a act of popular TV show for decennium , and one that continue its runnel and does n’t seem to be stopping anytime soon isGrey ’s Anatomy . create by Shonda Rhimes , Grey ’s Anatomypremiered on ABC in 2005 and has been unstoppable , even though its timber has decrease over the years and its most pop characters are now conk out .

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grey ’ Anatomyhas become know for not being the good at handling the deviation of its most popular characters and for the many behind - the - scenes tilt it has been involved in , of which many have resulted in main actor leaving the show . Of naturally , notevery actor has leftGrey ’s Anatomydue to scandals and government issue with Rhimes and the producers , with many of them just choose to search other acting chance and leave the hospital behind . Here ’s why every main graphic symbol left inGrey ’s Anatomy .

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Isaiah Washington’s Preston Burke – Season 3

Isaiah Washington played Preston Burke , the Head of Cardiothoracic Surgery at Seattle Grace Hospital . Burke was in a relationship with Cristina Yang and amaze engaged , but he left her on their nuptials day and renounce immediately after , leavingGrey ’s Anatomyin time of year 3 . Burke repay in time of year 10 to offer Cristina his smear at the medical research institute he founded in Switzerland , which she accepted . Washington ’s departure fromGrey ’s Anatomywas involved in a mess of controversy , as it was the result of a lot of on - set drama with his carbon monoxide gas - stars , most notably an argument with Patrick Dempsey where he used a homophobic smirch , presumptively directed to or in reference point to T.R. Knight .

Kate Walsh’s Addison Montogomery – Season 3

Addison Montgomery was the head of neonatal surgery and OB and gynecology , and Derek Shepherd ’s ( Patrick Dempsey ) ex - wife who had an affair with his expert protagonist , Mark Sloan ( Eric Dane ) . Addison leftGrey ’s Anatomyin season 3 to star in the spinoff TV seriesPrivate Practice , and she reelect for a duo of episodes in time of year 18 . Walsh leftGrey ’s Anatomyto star inPrivate Practice , which came to an end in 2013 after six seasons , but as mentioned above , she in brief returned toGrey Sloan Memorial Hospital .

Brooke Smith’s Erica Hahn – Season 5

Erica Hahn was a cardiothoracic surgeon at Seattle Grace and a long - time rival of Preston Burke . She got involve with Callie Torres ( Sara Ramirez ) , but their relationship was complicated and did n’t last long as Callie was still figuring her gender out . Hahn ’s divergence fromGrey ’s Anatomywas very abrupt , as she simply quit , got into her car , and left . Smith ’s departure was ABC ’s decision , as studio EXEC were not well-off with where Hahns ’ family relationship with Callie was going , and some reportedly did n’t even like the character .

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T.R. Knight’s George O’Malley – Season 6

T.R. Knight ’s George O’Malleywas one of Meredith ’s fellow interns inGrey ’s Anatomy , and he quickly became a fan deary . George scramble to recover his way , and he of a sudden decided to join the U.S. Army in Iraq . Richard Webber kick in him his last Clarence Shepard Day Jr. off so he could spend time with his family , but on his manner home , he jumped in front of a bus to pull through a adult female ’s life , but he was left severely injured and disfigured . George was unrecognisable , and it was n’t until he trace “ 007 ” on Meredith ’s hand that they knew who the inscrutable affected role was . George ’s brain well up during surgery and was later declared brain dead . Knight ’s deviation was due to a “ gradual dislocation of communicating ” and some behind - the - scene drama , as Rhimes reportedly monish him from come out and Knight was n’t well-fixed withwhere George ’s story was plump .

Katherine Heigl’s Izzie Stevens – Season 6

Izzie Stevens was also one of the interns whose journey began alongside Meredith ’s inGrey ’s Anatomyseason 1 . Izzie was diagnosed with malignant neoplastic disease in time of year 5 and eventually recovered , but she was fire sometime later after give the incorrect dose of medicinal drug to a patient role . Izzie leftGrey ’s Anatomyin season 6 , move to Seattle to bug out a fresh life and sending divorcement paper to Alex Karev ( Justin Chambers ) . Heigl ’s going fromGrey ’s Anatomywas one of the most controversial , and it all begin when she turn down to put her name forward for condition at the Emmy Awards , saying she had n’t been given enough material to justify a nominating address . This , along with reports ofHeigl being very difficult to sour with , led to her departure .

Chyler Leigh’s Lexie Grey – Season 8

Lexie Grey was Meredith ’s half - sister , and she joinedGrey ’s Anatomyin time of year 3 . Lexie ’s death was one of the most tragical 1 in the show ’s history , as it was a result of one of the most traumatic events in the serial : the planing machine crash . Lexie was crushed by a piece of the plane , injuring her pelvis , legs , and left subdivision , and fail minutes after being establish but not before saying goodbye to Mark Sloan . Leigh ’s conclusion to leaveGrey ’s Anatomywasn’t settle on behind - the - scenes dramatic play , as she merely decided it was time to close Lexie ’s arc and spend more time with her family .

Eric Dane’s Mark Sloan – Season 9

Mark Sloan was the top dog of pliant surgery at Seattle Grace Mercy West Hospital , and just like Lexie , he expire as a resultant of trauma from the planer crash . Cristina did her skilful to help Mark until they were rescued , but inGrey ’s Anatomyseason 9 premier sequence , Mark was on life keep , and as set by his will , the machines were turn off . Eric Dane leftGrey ’s Anatomybecause he was interested in other projects , but Mark Sloan became one of many characters who were belt down off .

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Sandra Oh’s Cristina Yang – Season 10

Cristina Yang was also an intern alongside Meredith , and she became one of the most authoritative characters inGrey ’s Anatomyas she was Meredith ’s serious acquaintance and “ person ” . Cristina ’s fourth dimension to leave Seattle and the series come when Burke offer her a line as the head of the hospital he founded in Switzerland , and as she had always been fiercely free-enterprise , focused , and challenging , she could n’t have this opportunity fall . Oh had been thinking about leaving the show for at least a year , as she felt it was sentence to allow Cristina go .

Patrick Dempsey’s Derek Shepherd – Season 11

One of the most shameful and heartbreakingdeaths inGrey ’s Anatomywas Derek Shepherd ’s , as he and Meredith were the show ’s main duet . After a lot of hassle in their marriage , Derek decided to move back to Seattle from DC , but on his way to DC to relinquish , he got into a automobile accident . Derek could n’t be saved , and he was hit from sprightliness support . Dempsey ’s decision to leaveGrey ’s Anatomywas a compounding of him feeling it was clip to leave the show and on - jell conflicts with Rhimes , Pompeo , and many other cast member .

Sandra Ramirez’s Callie Torres – Season 12

Callie Torres was the head of Orthopedic Surgery , butGrey ’s Anatomypaid more attending to her personal life , as she was in an on - again - off - again relationship with Mark Sloan , got involved with Erica Hahn , and married and by and by divorcedArizona Robbins ( Jessica Capshaw ) , though that was n’t the remnant of their kinship . Callie move to New York with her and Mark ’s daughter , Sofia , and leftGrey ’s Anatomyin season 12 ,   with Ramirez ’s decision ground on find it was sentence to leave .

Jessica Capshaw’s Arizona Robbins – Season 14

Arizona Robbins was the Head of Pediatric Surgery and one of the “ Seattle Grace Five ” , as she was one of the survivors of the plane clash . Arizona leftGrey ’s Anatomyin season 14 after her daughter , Sofia , moved back to Seattle , but she was deep infelicitous and missed Callie , so Arizona decided to move to New York so Sofia could be tightlipped to her and Callie . As for why Capshaw leftGrey ’s Anatomy , the electronic internet reportedly wanted to go in a dissimilar originative focus , so Arizona ’s prison term had to add up to an end .

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Justin Chambers’ Alex Karev – Season 16

Alex Karev ’s departure is one ofGrey ’s Anatomy ’s most controversialones – he was n’t killed off , but his termination took many , many stair back . Alex went to Iowa to supposedly help his mom but that was n’t lawful , and he told his married woman , Jo , that he was “ going through something ” before he stopped serve her calls . It was later revealed that Alex had reconnected with Izzie and determine she had Gemini thanks to frozen conceptus , meaning they were Alex ’s children . Alex decided to move in with her and their kids , and so he entrust Seattle . Chambers leftGrey ’s Anatomyto diversify his acting function , and it ’s unknown if Karev will ever turn back .

Giacomo Gianniotti’s Andrew DeLuca – Season 17

Andrew Deluca was one of Meredith ’s love interests and one of the most beloved characters inGrey ’s Anatomy . Deluca was in a constant engagement with his genial health , and it devolve in season 16 , to the dot where Miranda Bailey ( Chandra Wilson ) did n’t believe him when he tell her about a patient role who was the victim of human trafficking . Deluca had a grand dying as he was stabbed while inquire that human trafficking character . Gianniotti ’s departurewas a web decision .

Jesse Williams’ Jackson Avery – Season 17

Jackson Avery joined the hospital as a effect of the merger with Mercy West and became question of plastic operating theatre . Avery left inGrey ’s Anatomyseason 17 as he decided to make a change through his family ’s foundation after facing severe racial inequity . Jesse Williams explainedhe decided to leaveGrey ’s Anatomybecause he begin to find “ progressively safe , protected , insulated ” , so he moved on to different persona .

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Why every main Greys anatomy character left

Preston Burke Isaiah Washington Greys Anatomy

Addison smiling in Grey’s Anatomy

Erica learns about Izzie’s involvement in the LVAD wire incident in Grey’s Anatomy

George O’Malley leaning against a window and looking at something.

Katherine Heigl as Izzie on Grey’s Anatomy

Lexie at the beach smiling in Greys Anatomy.

Mark Sloan leans forward in his doctor’s coat in Grey’s Anatomy

Cristina Yang with her hands together looking serious in Grey’s Anatomy

Derek leaning against a wall in Grey’s Anatomy

An image of Callie smiling to someone off screen while she has a drink at Joe’s Bar in Grey’s Anatomy

Arizona looking scared on Grey’s Anatomy

Alex in a suit and tie on grey’s anatomy

An image of Andrew DeLuca leaning against a wall in Grey’s Anatomy

Jackson at the hospital looking serious in Grey’s Anatomy