Grey’s Anatomy
The pop medical dramaGrey ’s Anatomyhas been home to many iconic television couples over the preceding 20 years , including the likes of Derek and Meredith , Callie and Arizona , and Cristina and Owen . While the show has narrate many enceinte sexual love stories , it has also broken up the span with traumatic and tragical storylines .
Grey’shas never shy forth from severalize heartbreaking tales , but most times that has fall with the danger of killing off lover - favorite character and deflower beloved relationship . Plenty of terrible thing have materialize to individual case onGrey ’s Anatomy , but some of the worst things have happened to couples when they were together .
Amelia & Link: His Proposal
For a brief moment inGrey’shistory , it seemed like Amelia had finally see her happily ever after with Link . The two had a respectable kinship in the seventeenth time of year , with Amelia giving birth to their Word Scout and them giving off the vibes of a happy fellowship .
thing quickly took a routine when Link beat down on one genu , causing Amelia to flee the relationship . The two of them did n’t quite see optic to eye on the futurity of their romance , which led to the end of it . While there still seems to be a slight bit of promise for the dear couple , both parties seem to be move on in the eighteenth time of year .
April & Jackson: Losing Samuel
April and Jackson were an unlikely mates when they first got together onGrey ’s Anatomy , but their love write up turned into one of the most credible , romantic I on the show , to the decimal point thatsome fans even think deserves a spinoff .
April and Jackson went through a raft at the beginning of their relationship but always ended up line up their room back to one another . thing got especially tough though when April give birth to their first tike , Samuel , untimely . His medical condition caused him to blow over away before long after his birth , putting a nervous strain on April and Jackson ’s union that could never be fully repaired .
Callie & Arizona: Arizona Losing Her Leg
Arizona and Callie were a strong , loving relationship onGrey ’s Anatomy , and it seemed like they may actually get a happy end . That was rise to be untrue when Arizona got badly injure in the airplane clangoring , causing Callie to play a role in making the difficult determination of cut off her leg .
Arizona ’s surgery and amputation do a lot of thing to go wrong in their human relationship . Arizona felt like Callie would never rightfully understand the battle she went through by losing a arm and watching her Quaker become flat , and Callie tried to be supportive but finally failed to empathise what her married woman was going through . The traumatic case led to Arizona having an affair , a divorce , and an ugly custody struggle .
Richard & Adele: His Affair With Ellis
Richard and Adele had a complicated relationship from the very outset ofGrey ’s Anatomy , mostly due to mistakes on Richard ’s part .
Though he was a talented Chief of Surgery , Richard was n’t the heavy husband . His affair in the 70s and 80 with Meredith ’s mother Ellis led to a lot of tension and fundamental issues in his marriage to Adele , and his relationship with alcohol and inclination to exploit also contributed to their sadness .
Alex & Jo: Alex Visiting Izzie
After years of upward fictitious character evolution and many failed relationships and flings , it seemed likeAlex Karev had finally happen his soulmate in Jo Wilson . However , that all apace turned around when Justin Chambers announced his exit from the show , in effect ending the marriage between the two character .
On the show , Alex left for multiple episodes before returning via letter , informing his wife and close friends that he had choose to be with Izzie and their two children , something that both shocked and saddened longtime viewer . This sojourn to see his ex-wife - dearest was by far the regretful affair to happen to Jolex , as it was the nail in the casket for their love story .
Bailey & Ben: The Hospital Shooting
After a terrible first marriage , Miranda Bailey finally seemed to discover a guy who really care about her in Ben Warren during time of year 6 . However , her sexual love animation was put back when Gary Clark retrovert to Seattle Grace with a vengeance , causing a lockdown to occur as he jeopardise to drink down doctors .
After the traumatic event , Bailey determine that she want her space and could n’t be with anyone . The duet temporarily break up , but found their way back to each other . They ’ve been through a lot over late year , including a abortion , vocation changes , and cancer , but they ’ve been able to make it out stronger than ever before .
Lexie & Mark: The Plane Crash
Mark Sloan ’s clandestine daughter showing up at Seattle Grace pregnant could easily have been the worst matter to happen to Lexie and Mark as couple , but it was n’t .
or else , the worst affair to happen to the two of them was that just as they were finally ready to admit their love for one another , a planer crashed and ended both of their liveliness . The star - crossed lovers never got their felicitous ending and severalize each other they were " intend to be " at the last 2d potential . at long last , the two both transcend away and fans can fantasize that they made their way back to one another in the afterlife , lastly inhabit out their dreaming .
Izzie & Alex: The Hospital Merger
Izzie and Alex were a on the face of it pure couplein the early year ofGrey ’s Anatomy , breaking up and then come back together before Katherine Heigl ’s eventual exit from the show .
Izzie and Alex reconciled and married when Meredith gifted Izzie her wedding solar day , leading many viewers to trust that merrily ever after was in memory board for the on - again - off - again couple . However , Izzie and Alex ’s spousal relationship was over pretty quickly . The two were at odds after Seattle Grace merged with Mercy West , stimulate a surplus of operating surgeon and subsequent lay - offs . When Izzie thought Alex was subvert her problem so that she could recover , she ran off , never seen on - screen again .
Cristina & Owen: He Cheated On Her
Owen and Cristina had their fair share of problems onGrey ’s Anatomy . They did n’t always see middle to eye and rush into a marriage after a traumatic effect without by rights discussing their dreams for the future .
When Cristina revealed that she did n’t want children but Owen did , their marriage took a number for the bad . Things became more complicated when Owen began flirting with other women at the infirmary , and he eventually fink to Cristina that he had cheated on her , effectively ending their wedding . Owen ’s behavior was the fall of their relationship , causing it to no longer exist .
Meredith & Derek: Derek Died
Fan - favored couple Derek and Meredithwent through a lot together during their 11 season . They endure a secret estranged married woman , Meredith well-nigh dying double ( once at the hand of a bomb calorimeter and once by drowning ) , a infirmary shooting , plane clangor , and much more .
However , the ultimate cause of the iconic couple ’s death was when Derek was hit by a semi - hand truck in the 11th season . After failing to receive a brain CT at a nearby hospital , he was declared braindead and Meredith had to make the hard decision to attract him off life bread and butter . It was by far the hardest decision Mer had to make thus far , and ended their troubled relationship once and for all .
NEXT:8 Grey ’s Anatomy Characters Who Deserve A Spinoff
