Grey’s Anatomy

Of all the TV dramas , Grey ’s Anatomywould definitely outfit in the " heartbreaking " category . If this was its own musical style , the infirmary show would pull ahead , hands down . For almost 16 seasons , Meredith Grey(Ellen Pompeo ) and her coworkers / friend have loved hard , experienced loss , and kept hope even though sometimes it seemed like things were particularly horrendous .

Even though sometimes the show is lighter and Meredith and Cristina are dancing it out or the other doctors are laughing hysterically , there are a slew of tough , dark moments .   Here are the 10 most heartbreaking scenes from the first time of year ofGrey ’s Anatomy .

Izzie Gets Dumped

It ’s hard to even remember that Izzie Stevens ( Katherine Heigl ) had a love life before meetingAlex Karev(Justin Chambers ) and Denny Duquette ( Jeffrey Dean Morgan ) . Those are her two most important ( and most grievous ) romances .

But back in the first season , Izzie had another swain , and in the instalment   " Shake Your Groove Thing , " he ditch her . Why ? Because now that she ’s going to be a Dr. , he feel that she manage more about that than him . It does n’t aid matter that she scrubs in on a OR when she ’s supposed to be host a gathering for him … but it ’s still pretty sad to watch this angelical character get dump .

Alex Discovers Izzie’s Modelling Days

From the instant that Izzie is introduced , it ’s absolved that she ’s very attractive . As it turns out , she used to be a model .

Alex unwrap this part of her biography and tries to embarrass her by letting everyone at the infirmary know in the instalment " No Man ’s Land . " He puts exposure in the locker room and she ’s now " Dr. Model . " This is a super mean thing to do and just essay that Alex has quite the change of heart as he becomes such a good somebody later on in the show .

Bailey Learns About Derek And Meredith

It ’s clear from the pilot when Meredith and Derek hook up ( and then learn that they ’re both bring at the same hospital ) that someone is going to learn what ’s lead on . When Derek and Meredith fall out in his car in " shake up Your Groove Thing , " it ends up being Miranda Bailey ( Chandra Wilson ) who view them .

This is not only an inapt conniption but also break our ticker when intend about it since anyone would think that it ’s unprofessional for Derek and Meredith to date . But as true fans of the show know , these two are signify to be together and have a real love tarradiddle ( that , of course , terminate in tragedy ) . It does n’t matter what anyone else intend . Derek and Meredith have to keep up their hearts , and thankfully , they do .

Zoey, The Pregnant Woman With Cancer

In the first time of year instalment " Save Me , " Cristina meets Zoey Glass ( Joan McMurtrey ) who has become pregnant even though she did n’t think it was potential . While that would of course be a happy social function , she also has breast cancer .

take a leak matter even more heartbreaking is how Cristina deal with her . Cristina ca n’t conceive that Zoey want to keep her baby knowing that she will die from her Cancer the Crab . Cristina has her own personal connection to this subject as she ’s expecting a child herself but has never wanted children , so she ’s having difficulty coming to price with this .

Annie’s Case

In " If Tomorrow Never Comes , " the medico have a lawsuit that is truly heartbreaking : a adult female with a bounteous tumour that has been getting spoiled and worse . Annie Connors ( Alex S. Alexander ) tells George the Sojourner Truth : she did n’t get it take in to because hospital gross out her out and she has lost too many people .

If that ’s not lamentable enough , she does n’t survive the infirmary visit . It ’s always problematic to catch the Dr. struggle to save someone , and this was one of the worst medical case of the first season .

Izzie’s Patient In “The Self-Destruct Button”

In the season one installment " The Self - Destruct Button , " Izzie has a affected role who , at first glance , might be meant to make audience laugh . His plot line is a little silly : JP ( Bill Birch ) actually ate the keys to his girlfriend Athena ’s ( Ever Carradine ) berth because he ’s so in love with her .

But this is in reality really sad , and he took his lovemaking to such a crazy extremum that it affect his respiration and it ’s super serious . It ’s sturdy to think about actually doing something like this , and it ’s a reminder that a hatful of the patients who come into the hospital onGrey ’s Anatomyare in a lot of aroused ( as well as physical ) pain .

Derek Picks Meredith For A Big Surgery

In the pilot , " A Hard Day ’s Night , " Derek Shepherd ( Patrick Dempsey ) is about to perform surgical procedure on a teen girl and picks Meredith … but , oops , Meredith had already pick Cristina Yang ( Sandra Oh ) .

While at first this might not seem like a very braggy deal , it ’s actually heartrending when we look at the dynamic of Cristina and Meredith ’s friendly relationship . From the very kickoff , they ’re each other ’s " person " and they always get each other . But they are also both fiercely ambitious , brilliant , and competitive , which means that sometimes , that ’s proceed to get in the way . We can definitely feel the tension here .

Cristina’s Pregnancy

Cristina Yang has never require to be a female parent , which has led to some tough times in her relationship with Owen Hunt ( Kevin McKidd ) . The part has an miscarriage , which is widely praise as a brave tv set minute .

In the first season , Cristina is pregnant , which was n’t planned and it ’s not something that she is prepared for . This is one of season one ’s toughest , most heartrending moments as Cristina has to plow with a lot of emotions on this topic . She knows that she ’s not ready to be a mamma and that having kids is n’t in the cards for her . While it ’s a really knockout situation to be in , the show merit a circle of credit entry for portraying a woman who is listening to her gut and making the right option for herself .

Fans Learn About Meredith’s Awful Family Life

In " shake off Your Groove matter , " Meredith goes to see her mom , Ellis Grey ( Kate Burton ) , and fan memorise about Meredith ’s really difficult upbringing . It becomes clear that Ellis has Alzheimer ’s and is n’t able to truly connect with her daughter anymore .

alas and tragically , the two never had a distinctive female parent / girl family relationship … or even anything resemble a adhesion at all . When Meredith was little , her mom always chose the hospital over her , and Meredith never felt have sex or worry for . AsGrey ’s Anatomygoes on , fans will notice that Meredith was there when her mum tried to kill herself .

Derek Is Actually Married

The most heartbreaking moment in the first time of year ofGrey ’s Anatomyhas get to be when sports fan ( and Meredith ) memorise that Derek is really married . When Addison Montogmery ( Kate Walsh ) is suddenly at the infirmary , it turn out that ( whoa ) she ’s Derek ’s married woman .

This was such a monolithic moment on the show and really started moving Meredith and Derek ’s family relationship in a new , super dramatic way . Now Meredith has to deal with her feelings and project out what ’s going to chance next .

NEXT : Grey ’s physical body : 10 Storylines That Were Never resolve

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A photo of Izzie modeling on Grey’s Anatomy

Derek flatters Meredith during her intern year in Grey’s Anatomy

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Derek and Meredith standing together looking concerned on Grey’s Anatomy.

Cristina Yang looking concerned on Grey’s Anatomy

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Derek and Meredith talk to Addison on Grey’s Anatomy

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