Grey’s Anatomy
Grey ’s Anatomyhas been on the air since 2005 . Throughout fifteen seasons , it has captivated audiences and been a invariable in several viewers ' life . The serial is the longest - range aesculapian dramatic event on tv set and overall , one of the most famous show ever . Everybody knows ofGrey ’s Anatomy , even if they have n’t actually discover it .
This serial publication is completely iconic , and still manages to be extremely successful , even after many of the original principal characters have long since been written out of the show . To maintain its massive succeeder , Grey’smust be doing something right , and that something is its relationships .
The dramatic event , friendships , and romanticism systematically keep fans coming back for more , no matter how many heartbreaking breakups they ’ve had to endure throughoutGrey’sfifteen time of year . With as many powerful relationships as this show has and has had in the past , there have been just as many breakups that have alter the show and destroy fans hearts . rent ’s take a look at 10 ofGrey ’s Anatomy’shardest - hitting breakups .
10. IZZIE STEVENS AND ALEX KAREV
Grey ’s Anatomy ’s massive winner began to dwindle away upon Izzie Stevens ' departure from the show , which had been triggered by a feud between actress Katherine Heigl and show runner Shonda Rhimes . The infamous feud away , Izzie Stevens was one of the most compelling characters ever to look onGrey ’s , and is still a fan - favourite to this day .
Not only did her exit serve to injure the show , but her good luck - up with Alex Karev also drastically upset the fanbase . Izzie and Alex had an ongoing romance for a while , and devotee absolutely love it . So when the show began to threaten that beautiful dynamic - and at last destroy it in the most disrespectful way - viewers were understandably lay waste to .
9. JACKSON AVERY AND APRIL KEPNER
Jackson and April were the dream team . Though they had a rollercoaster - ride of a kinship , and were the beginning of plenty of drama , many sports fan adored this mating . By the timeGrey’sdecided to put the axe to this longterm romanticism - and finally , compose the dear April Kepner out of the show - fans had been through so much with the couple that the demise of their shackle was very upsetting .
Jackson and April ’s moral force , combined with Sarah Drew and Jesse Williams ' undeniable chemistry , made fans root for these two passionately . Through their transition from friend to buff , their first breakup , Jackson break up April ’s wedding to tell her his truthful impression and them turn tail by together and eloping , to the death of their infant son and the birth of their girl … many spectator really just want to see Jackson and April figure out it out , but ultimately , Grey ’s Anatomycrushed that dream .
8. MARK SLOAN AND LEXIE GREY
McSteamy was one ofGrey’smost iconic fictitious character . He first appeared in time of year 2 , and transport audience immediately with his spell and self-important yet endearing behavior . When Meredith ’s slight sister , Lexie , was introduced late in time of year 3 , this pairing seemed improbable .
But despite their geezerhood gap and very unlike personality , when Lexie and Mark struck up a romance , it was clear that they were mean to be together . And ultimately , they did terminate up together , but after much play and a tragical carpenter’s plane crash that lay claim both their lives . Mark and Lexie will incessantly be one of the most tragical romancesGrey’shas ever salute .
7. CRISTINA YANG AND MEREDITH GREY
Though this was not technically a break - up - at least not aromanticbreak - up - Cristina Yang and Meredith Grey had what is view by most as the most iconic friendly relationship onGrey ’s Anatomy . The dynamic these two had start inGrey’spilot episode , and their bond grew from there , until finally they became each other ’s somebody .
In season 10 , Cristina leave Grey Sloan Memorial for a job in Switzerland . Her last time of year is a grievous one , which in many different episodes , salute Cristina debate certain aspects of her life , such as her romance with Owen . At the end of the season , Cristina leaves for Switzerland , after one last " dance it out " sitting with Meredith . Cristina ’s departure was arguably one of the most grievous instances on the show , and this was largely due to the fact that fans had to say good-bye to Meredith and Cristina ’s awful friendly relationship .
6. ALEX KAREV AND REBECCA POPE
Alex Karev has been through a circle . found his repute as the bad boy who is a bit of an derriere but actually has a sum of gold , early on in the series . For a eccentric that Shonda Rhimes did n’t even create until the pilot episode was already primarily shoot , Alex has become one of the most successful and beloved of the entire series . In time of year 3 , Alex heroically saves a woman who is trap under a prominent musical composition of metal after a tragical ferryboat boat crash . But his noble action has some damaging effect , as the charwoman he saves has amnesia , personal identity issues , and subsequently on , is bring out to be extremely mentally inauspicious .
5. PRESTON BURKE AND CRISTINA YANG
Preston and Cristina were one of the first romancesGrey’screated , and their relationship was off to a rough startle right from the beginning . Cristina suffered an ectopic maternity early on in their family relationship , and the seasons leading up to Preston ’s ultimate loss , would prove to be a dramatic rollercoaster for the couple . In season 3 , the two decided to get married , but this would turn out to be a fateful error for their relationship . The season coda revolved around the wedding , and by the end of the instalment , it was reveal that Preston had run out on Cristina .
4. ADDISON MONTGOMERY AND MARK SLOAN
Addison ’s affair with Mark was a giving part of the show for the earlier time of year . This relationship was a destructive one , doubtlessly . It fed into destroying Addison ’s marriage to Derek , and temporarily pose a rift and feud between Mark and Derek , who had been best friend since they were Thomas Kyd .
The biggest repercussion that Addison and Mark ’s break - up had , was Addison ’s ultimate departure fromGrey ’s Anatomy , and her transition to the twirl - off , Private Practice . It was great to see Addison get her own show , but she was sorely missed by theGrey’sfanbase .
3. MIRANDA BAILEY AND TUCKER JONES
This break - up may not have had much effect on the audience , but it was devastating for Miranda Bailey . The couple ’s Logos was a tot back then , and while their relationship had always been a little rocky due to Bailey ’s busy work schedule , the severance - up was fairly acute .
Shortly after an incident that put Tuck Jr. in the infirmary , Dr. Bailey and Tucker Sr . began to have some serious problems , and their ultimate divorce would hurt Bailey greatly .
2. RICHARD WEBBER AND ELLIS GREY
Ellis and Richard ’s relationship - though seen mostly through flashback - was one of the most crucial to the show . Their love story embark on when they were to untested interns at Seattle Grace . They were both marry , but they come down for each other all the same , and this was the beginning of a love story that would determine the show into what it is .
Ellis and Richard ’s human relationship still play a part in the show today - even now that Ellis is deceased - and Meredith would not be who she is , had it not been for their break - up .
1. CALLIE TORRES AND ARIZONA ROBBINS
Callie was one of the most captivating , iconic grapheme that ever existed in theGrey ’s Anatomyuniverse . Being introduced early in the second time of year , Callie had a whirlwind romanticism with George O’Malley , and later came out as bisexual , beginning a romance with Arizona in time of year 5 .
Callie and Arizona had an absolutely epic honey report , one that provide LGBTQ+ reputation and captured fan hearts for several seasons . This meant that their heartbreaking separation and divorce would serve to completely devastate viewers , and the loss of these two characters and their beautiful relationship , is one of the most impactfulGrey’slosses to date .
NEXT : Every Sizzling Season Of Grey ’s Anatomy So Far , Ranked
