Grey’s Anatomy
The sheer number of breakups onGrey ’s Anatomy ’s book run is staggering . This Shondaland play has split couple up at the drop of a chapeau , but while some relationships end without much dissonance , others like the separation of Jackson Avery and April Kepner have had fans reach for their tissue .
separation are intemperate , especially when it ’s a beloved duet like Mark and Lexie or an adorable one like Alex and Jo . Then there are the polarizing pairings like Teddy and Tom or Meredith and Andrew , but irrespective of whether the brace made sense or not , within the linguistic context of their own story , these detachment hurt .
Meredith & DeLuca
Meredith ’s first literal relationship after Derek ’s tragic passing was with Andrew DeLuca . fan might have been of two minds about their interpersonal chemistry but there is no dubiousness that their separation was disheartening .
Meredith had been through terrible challenge in her life story already , and fans are always hope that she finally find out some happiness . Here she was , just commence to dim her feet into the go steady pool again , and she really seemed happy with DeLuca . Alas , he broke up with her in time of year 16 , leaving devotee wondering yet again whether Meredith was specify to ever really be happy .
Meredith & Derek
Derek and Meredith might have seemed like the gross couple , but thing presently turn moody when the former was reveal to be married . Addison ’s arrival at Seattle Grace at the end of time of year 1 sent Derek and Meredith ’s relationship coil , and there was a phase in time of year 2 when the pair seemed to be going their separate way .
The two parted direction yet again in season 4 when Meredith come out hesitant to commit to the relationship . They continued to go through ups and downs with both of them dating other the great unwashed . Their legal separation menstruum was one of nifty torment for fans as they waited with bated breath for their favorite twosome to reunite . Their thwarting grew even more , as MerDer ere intelligibly mean to be together .
Link & Amelia
Link and Amelia quickly became an adorableGrey ’s Anatomycouple after they depart hooking up and Amelia became pregnant unexpectedly . The time of year 17 stopping point ended with Amelia being unable to take Link ’s proposal and the latter seek refuge with his good friend Jo .
Link and Amelia work because their relationship seemed , to bring home the bacon Amelia with a shade bit of constancy — for once . As someone who had been through tremendous hurt in the past , devotee hoped that Amelia would finally take in a shift . Yet , it seems like felicity is still going to parry her for a while since in time of year 17 she was record questioning her current situation .
Owen & Cristina
Cristina ’s prolong romance with Owen take her on a roll coaster ride . The two broke up more than once as they kept reconciling at some level . But the final breakup in the season 9 last was grievous , especially since both had put in a batch of movement to relieve the human relationship .
After helping each other through post - traumatic stress , they finally split up over the dissimilar living they envisage for themselves . Seeing them unable to keep their hands off each other but knowing that they could n’t be together was crushing for many a fan .
Tom & Teddy
Tom and Teddy were one of the more recent couples to secernate . Grey ’s Anatomyfans may have divided opinions on Tom , but for all his irony , he was genuinely in dearest with Teddy . He had been through a fair bit of tragedy in his own living , having suffer his son to an fortuity , and it seemed unfair somehow that the one somebody at Grey Sloan Memorial who saw his softer side did n’t at long last prefer him .
In one of the most touching minute in the Tom - Teddy - Owen trilateral , Tom was seen putting together a cribbage for Teddy ’s baby while the latter was give nascence with Owen by her side . Teddy finally expose it off with Tom once and for all in season 17 .
Jo & Alex
In one of the worst separation inGrey ’s Anatomyhistory , Alex stop up with Jo in season 16 in a Dear John letter redolent of the one Izzie compose to him age ago .
The detachment was tremendously unfair to Jo , who had been live with depression and needed all the support she could get from her husband . For Alex to leave alone her then made very niggling sensory faculty for a persona that had evolve with bound and bounds over the class . Furthermore , the separation marked Alex ’s going from the show after 16 recollective years , and that by nature broke fans ' bosom .
Callie & Arizona
Callie and Arizona were one of the great lover - pet span on the show . However , like every Shondaland character , these two went through some terrible fourth dimension , which pushed them away from each other .
lover felt gutted in season 11 when Callie told Arizona that she had grown to bask her time away from her and require more of that independency . Their separation might have been a farsighted time coming , ever since the annihilating sheet clank in season 8 . The couple ’s rip mean that they had turn tired of their constant friction and Callie , require a lifetime that did n’t orb around Arizona , especially after the latter became one of theworstGrey ’s Anatomycharacters to have cheatedon her mate .
Izzie & Alex
Grey ’s Anatomyfans spend years moving on from Alex ’s breakup from Izzie , as they were a fan - favorite twosome who were two of the original interns in the show .
Izzie and Alex onGrey ’s Anatomydidn’t always make sense , but there was an component of spell in how Alex embarked on his path to bettering himself . The two broke up at first over a misunderstanding when Izzie erroneously believe Alex had canvassed to get her fired , and then finally in time of year 6 when he let her go .
Lexie & Mark
Mark and Lexie had one of those heartrending on - and - off relationship that kept sports fan perpetually scotch . The two were made for each other but never bring forth around to putting their feelings above other petty proceeds during their fourth dimension at Seattle Grace .
They break up in time of year 6 when Mark seek to railroad Lexie into take on a life where his newfound adolescent daughter and her newborn would survive with them in the same theater . Since then , the couple shared moments when they almost got back together but never amply did . The older , arrogant Mark was abase by the jr. , gentler Lexie , and fans wish well that they would ultimately estimate thing out . Of course , that was never to be as Lexie pop off shockingly in theseason 8 close ofGrey ’s Anatomy , with Mark following suit of clothes , thereby rendering their love tale and separation even more poignant .
Jackson & April
One of the most heartrending breakup onGrey ’s Anatomywas that of Jackson and April . The two had gratifying interpersonal chemistry and sustain together very dramatically when April ran away with Jackson at her own wedding , depart Matthew high and wry at the altar .
Unfortunately , Jackson and April ’s romance and marriage were pregnant with stress and tragedy : their little son , Samuel , was diagnosed with a rare pearl disease that stimulate his death hours after his nativity . The pain was unendurable , and the couple separate in the time of year 11 finale and finally divorced .
NEXT:10 Best Stormy Relationships From Grey ’s Anatomy , Ranked
