Grey’s Anatomy

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The medico onGrey ’s Anatomysee death all the sentence , and their life ’s work is to save the patient role who come into the infirmary . While loss is the toughest part of their Job , they   also have to say adieu to friends , co - workers , and family members throughout the show ’s 17 season .

Meredith has lost the most people airless to her , including several relatives and the love of her life , and the other lineament have lost some important people as well . ManyGrey ’s Anatomyepisodes include big role death that certainly made fans passing emotional .

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‘Some Kind of Miracle’ (S3 Ep17): Ellis Grey

One of the first major death in the series was Ellis Grey , who died in time of year 3 . Throughout the first three seasons , Ellis had been living in a residential facility after she had been diagnose with Alzheimer ’s ; however , her wellness was see to it to deteriorate as she was admit to the hospital several times due to a serial publication of physical illnesses too . regrettably , after she had heart OR , Ellis never recovered and deplorably evanesce away .

This was one of the most lifespan - spay moments for Meredith , whofaced many problems in her spirit , and it was difficult for her to lose her mother bonk that they never get the chance to really utter , connect , or say that they loved each other one last time .

‘Losing My Religion’ (S2, Ep27): Denny Duquette

After Izzie fell in love with Denny , she cut his LVAD telegram and almost had to step away from medicine always . Sadly , Denny did n’t make it after he had a stroke come his middle transplant .

Denny ’s season 2 death is one of the most tragical and memorable on the show . Izzie desire that they could stay together and while some questioned her feelings for a patient and how appropriate that was , she feel that their connection was too strong to leave about . This was , by far , one of the most excited storylines on the show .

‘Suddenly’ (S8, Ep10): Henry Burton

He may not have been one of the sawbones , but Henry did have a major wallop on fans . Sadly , Henry ’s time on the show was shorten short after he died on the operating table following the uncovering that he had a tumor close to his heart .

This was one of the hardest things that Teddy ever went through , as   she require to be able-bodied to help him . Although they got married for the purpose of him using her wellness policy , they did have real feelings for one another and gradually go down in passion . watcher uprise invested in Henry and were sad to say so long .

‘Death And All His Friends’ (S6, E24): Charles Percy

In   this tragical episode from time of year 6 , Gary Clark shot Charles Percy after inquiring if he work as a surgeon . Bailey was there and assay her well to relieve his life , but as they could n’t get into an elevator to get him in an operating room , he woefully did n’t make it .

fan unquestionably felt emotional when looking back at Charles ' last moments , which see to it him open up to Bailey .   When he rent Bailey know much she mean to him before passing forth , it was unsufferable not to tear up .   This was one of the more heartbreaking episodes inGrey ’s Anatomytoo , asCharles was n’t the only person to be kill .

‘Helplessly Hoping’ (S17 Ep11): Andrew DeLuca

One of the more surprising deaths occurred in season 17 when DeLuca was killed trying to break a human marketer from break loose . This was a shocking character last that took everyone by surprise as lover   had been confident that he would recoup .   With DeLuca also having a memorable dear level with Meredith , fans had been wondering if they would reunite at some power point too .

time of year 17 had many   great scenesand in a season with so much lugubriousness and infliction , this one is tough for fans to consider about . DeLuca was a kind soul and this was a peculiarly terrible way for him to go .

‘Going, Going’ Gone' (S9, Ep1): Mark Sloan

While it seemed as if Mark Sloan would survive after the plane crash in the season 8 close , he did pass aside while he was in the hospital . Mark and Lexie ’s love account had so much likely and their future seemed so near , but they both tragically died middling closely together , and no one could think that this is how it end .

While it was knotty to say good-bye to this beloved eccentric , viewers love Mark ’s advice to Jackson , tell him to hear to his heart and not waste any time in   sharing his feelings for someone .

‘The Winner Takes it All’ (S15, Ep11): Thatcher Grey

Although he did not feature as much in the show , Thatcher Grey ’s last still had a major wallop on Meredith since there was so much unresolved chronicle between them .

Meredith felt that she had been abandoned by Thatcher since he allow for when she was younger , and she did n’t think that he put much time and effort into their relationship once she was older . She still felt really gravely about their father / daughter relationship when he died , and she realized that she would never really be able to move on from that .

‘Now Or Never’ (S5, E24): George O’Malley

In one of the more heartbreaking second in season 5 , everyone was taken aback to discover that George O’Malley was the cryptic patient role that had been hit by a bus . They had only discovered this when he wrote " 007 " in Meredith ’s bridge player .

This can be seen as the first   big death of a main role on the show , as George was part of the original intern group and no one suppose him ever leaving . The other characters turn a loss a good friend who felt like home , and it was specially tough for Meredith , who felt that she was invariably losing the great unwashed close to her .

‘Flight’: (S8, Ep24): Lexie Grey

Lexie died before Mark did as a result of the plane crash , and it was not only shocking to see such a fearful outcome on the show , but it was awful to watch this sweet and popular character pass aside .

This death was one of the worst as before Lexie die , Mark was powerful there , telling her that they would have a beautiful living together . Fans were just as heartbroken as Mark was when she was lead ; whiletheir love affair was n’t complete , they both seemed altogether quick to commit , and   they did n’t need to be with anyone else .

‘How To Save A Life’ (S11, Ep24): Derek Shepherd

When he   was head to Washington so he could stop working for the President , Derek saw a gondola accident and he wanted to help . However , after he wangle to get everyone patched up and commence to leave the setting ,   his car was hit by a truck . Although Derek could have been make unnecessary , he woefully passed away when the doctors give out to bring in that he had a hard brain bleed .

This season 11 episode featured   what is   arguably the heavy character death onGrey ’s Anatomy . It was tragical to imagine the ramifications of this minute : Meredith put up their shaver without her soulmate and love of her life , Derek ’s kinsperson exist without him , and his co - workers who had become family having to grieve the loss as well . Meredith   spent some time away from Seattle and give birth to their third babe , a beautiful admonisher of their dearest storey .

NEXT : The Main Characters On Grey ’s Anatomy , Ranked By Meanness

A split image of Mark lying in a hospital bed and Meredith lying with Derek after his death in Grey’s Anatomy

Ellis Grey on Grey’s Anatomy

Izzie in bed with her patient, Denny.

Teddy and Henry looking at each other in Grey’s Anatomy

Charles Percy on Grey’s Anatomy

Deluca in Grey’s Anatomy

Mark Sloan on Grey’s Anatomy

Thatcher Grey on Grey’s Anatomy

George O’Malley leaning against a window and looking at something.

Lexie and Mark at the bar

Meredith lying with Derek in the hospital on Grey’s Anatomy