Grey’s Anatomy

Viewers always love a good conflict , and this is in two ways interesting where human relationship are concerned . Grey ’s Anatomyhas been masterful for having many couple who have a habit of challenge one another due to one problem or another , and there have been some that are the pick of the caboodle .

Almost every main character from Meredith , Derek , Callie , Cristina , and more , have had effect with their amatory interests - ranging from factor like former lovers return , commitment issues , and certain tragedies . With the serial publication move into its eighteenth time of year , it ’s worth checking out which pair in the history of Grey - Sloan Memorial have supervise to capture the fanbase ’s attention with their see - saw dynamic .

Mark & Lexie

Although they ’re considered soulmates , Mark and Lexie had a lot of hurdles in their relationship that were at last only solved due to their deaths . The pair ’s military issue stemmed from Mark ’s long - turn a loss daughter butting heads with Lexie , along with both dating the awry citizenry when they were in love with each other .

Yet , there was something appealing about the bubbly personality of Lexie deep impacting the immature but well - meaning Mark . It was always felt as if they would find a elbow room to be together despite stumbling their way toward it . In the conclusion , it was only in death did they finally reunify .

Derek & Meredith

His status as a buff favourite means there is very fewunpopular ruling about Derek inGrey ’s Anatomy , although he did exhibit some bad side in his troubled relationship with Meredith . Their problems arise through issues like Derek still being married to Addison , Meredith ’s commitment issue , and their disagreements over whose life history was more important .

All thing considered , it was still the main mating of the show , with the couple lasting a whole decade . Their reconciliations were extremely search by the fanbase , as one of the likable constituent about the couple was watch them have the best conflict .

Cristina & Burke

This relationship was all about one - upping each other , in many ways . After all , Cristina take she wanted to become what Burke was , imply she was attracted to the approximation of him as a successful surgeon . Of of course , both of their egos got in the way of that , making for a complex love write up .

The conflict in this conjugation was their unfitness to amply pull up stakes their comfortable headspace , such as Cristina being unsure of the wedding or her compromising her notion , which she valuate most . Then again , it was this very tone that allowed this relationship to extend out for so long , as it delimit both of their characterisation .

Jackson & April

These two could have been the happiest couple on the show due to their cheerful personalities , but Jackson and April ’s indecisiveness always became a barrier . They delayed getting together for year purely due to being timid how the other mat , while they could n’t be felicitous apart either , and April ’s marriage with Matthew end because of the ghost of her love for Jackson .

Fittingly , though , their last second on - CRT screen saw them move aside together , as Jackson and April always found a way back together . The stormy nature of their kinship also carry a rainbow of Bob Hope at the final stage of it , with either character always making a grand declaration of love and support to start up things up again .

Alex & Jo

The breakup of their marriage wasone ofGrey ’s Anatomy ’s predictable plot twists , chiefly due to Alex and Jo having done it quite a lot before . They were always pretend by extraneous factors like the matter of Jo ’s past identity operator and Alex ’s lingering feelings for Izzie .

fan were still soured when Alex leave Jo for Izzie , as his relationship with Jo seemed to only be further strengthened after the end of each problem . The two had return with commitment in such a way that it was as if they were meant to be together to figure this aspect out .

Owen & Cristina

Owen was the everlasting contrast to Burke , in that he was sensitive , ambitionless , and out loud about his love for Cristina . However , their Latinian language still had its problems as her ambition was too great for him to accept and they ended up on two different sprightliness paths .

This clank between mentalities and their natural alchemy entertained fan for more than half a X , with their level playing out in twist and bit . Cristina and Owen ’s relationship may have been doomed from the offset , but the drama involved was certainly spicy enough to keep viewers engage .

Mark & Addison

Without a incertitude , this has to be the steamy dyad in the series , with their intimate present moment defining their family relationship . Of course , with so much heat between them , there had to be a pile of emotional stagger as Mark and Addison just could n’t get on the same page .

They were mostly attracted to one another when either was unavailable , having nobble up when she was married to Derek and when he was on a break with Lexie . Fans still bed the give-and-take between them and even though they were n’t endgame , it was n’t a full loss since their chemistry was still matte whenever they interact .

Richard & Ellis

Richard and Ellis ’ emotionally ravage affair was a storyline that has had a deep result on the characters and the show . They were the form of twosome who were thread to each other numerous times because it was forbidden , which meant they only carried on with it further .

Viewers were aware that they were incorrect to hurt their spouses and basically Meredith ’s childhood , but there are n’t many couples who have this degree of passion . It was equally interesting to see if Richard would go on his emotional affair with Ellis later in living , which express that fans could experience the same pull the characters felt up toward one another .

Alex & Izzie

The dynamic of Alex and Izzie was so great that they had multipleiconic couple scene inGrey ’s Anatomy . Her wish to be whip off her feet and his disinclination to be so mushy and romantic ended up making them an oddly tally twain . The two move the supernumerary mi to support the other during some hard times , such as Denny ’s dying or Izzie ’s illness .

There were just as many grief , with Izzie divorcing him without prior notice and Alex cheating on her . However , it was watching the many wondrous declarations of passion they did for one another that made this pair so entertaining , even if it came at the disbursal of such spectacular breakups .

Callie & Arizona

These two had perhaps theworst reasons to break in up inGrey ’s Anatomy , having ended their relationship multiple time . Whether it was Arizona ’s cheating , Callie rediscovering herself during their separation , or having a fight at an aerodrome , fans could count on this couple to regain a mode to fight .

On the other hand , there were also so many near times that Arizona and Callie come across as dependable friends who were married . They managed to be majuscule parents to Sofia , have a humourous friendship with Mark , and reconciled once again at the closing . This pair defined the aspect of having ups and downs in a human relationship but still loving one another , and their dissolution and reconciliations are both suitable of several highlight reel .

NEXT:10 Grey ’s Anatomy Characters Who Left The Show Too Soon

Grey’s Anatomy Poster

Split image of image of Ellis and Richard smile at each other and Meredith and Derek standing in the elevator in Grey’s Anatomy

Mark and Lexie at the bar

Meredith and Derek standing in the elevator in Grey’s Anatomy

Cristina comforting Burke after he got shot in Grey’s Anatomy

Jackson and April have an argument

Jo and Alex standing in the elevator in Grey’s Anatomy

Owen catching Cristina in Grey’s Anatomy

Addison and Mark smile at each other

Richard and Ellis hold each other and smile in Grey’s Anatomy

Alex and Izzie fighting in Grey’s Anatomy

Callie and Arizona look glum